Tributyltin oxide - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information Note : See Working with the Information on this Page section below for important notes about this data. The major TBT pesticide is tributyltin oxide. The effects of tributyltin (TBT) to the life cycle of the estuarine fish Cyprinodon variegatus were examined in a 180-day flow-through exposure. February 2008 Annals of Applied Biology 60(2):181 - 190 Toxicity of organotins in humans is most frequently reported as loss of memory and insomnia as well as other symptoms including death ( 4). There are no data in humans concerning development of cancer following exposure to tributyltin oxide (TBTO). However, little is known about its reproductive toxicity, For sperm cells, the toxicity of the two tributyl compounds was significantly greater than that of two triphenyl compounds; for embryos, the triphenyl compounds appeared to be more toxic. Tributyltin oxide (TBTO) has been widely used as marine antifouling composition, preservative, biocide, and a stabilizer in plastic industry. TBTO exposure caused serious histological damage to the testis, including reduction in counts of spermatids and spermatozoa and malformation of somatic cells around the seminal duct. Comparative toxicity of tributyltin-oxide (TBTO) for fish and snail. In Proc. Male Wistar rats received an intramuscular injection of 0.5 ml/kg bis (tributyltin) oxide. Chemical Status Basis Species Parameter Value Units Comments 013356-08-6 Fenbutatin oxide F CrE Rainbow trout LC50: 1.7 ppb/96-hr Fathead minnow LC50: 1.9 ppb/96-hr Daphnid EC50: 3.1 ppb/48-hr Bluegill LC50: 4.8 ppb/96-hr Sheepshead minnow LC50: 20.8 ppb/96-hr No information was located regarding toxicity of tributyltin oxide in humans following oral exposure. Summary of unpublished paper presented at the Fifty Annual.SETAC Meeting; Nov. 4-7, 1984, Arlington, Virginia. The stingray, Urolophus jamaicensis, may represent the ideal study organism for the adverse effects of TBTO to elasmobranches. Tributyltin oxide (TBTO) is an organotin compound chiefly used as a biocide (fungicide and molluscicide), especially a wood preservative. The toxic effects of bis (tributyltin) oxide (TBTO) on the rat liver were studied with an electron microscope and the accumulation sites of tin were determined with an X-ray microanalyzer. Pesticide properties for Tributyltin oxide, including approvals, environmental fate, eco-toxicity and human health issues The effect of nTiO2 aggregates on the toxicity of the highly toxic marine antifouling compound tributyltin (TBT) to abalone embryos was also investigated. Cancer bioassays following oral exposure have been conducted in rats and mice. There are several case reports claiming irritation of the respiratory No developmental effects of nTiO2 were observed at 2 mg/L but concentrations ≥10 mg/L caused hatching inhibition and malformations. The acute toxicity of tributyltin compounds has been studied on several species of freshwater fish. In an inhalation study with tributyltin oxide rats were exposed in nose only chambers for 4 hours 5 days a week for 21 -24 treatments for 29 -32 days. The acute 96-hour LC50 to freshwater fish ranged from 2.6 µg/L to 13 µg/L. Tributyltin Compounds. The present study was carried out to investigate the acute toxicity of TBTO and the effects of its sublethal concentration on brain AChE and gill ATPases activity of tilapia fish, Oreochromis niloticus during acute (3-96 h) and subchronic (7-28 d) exposure periods. PubMed:Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats. Chemsrc provides Tributyltin oxide(CAS#:56-35-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. PubMed:[Soil sorption of bis-(tributylin) oxide]. Previous studies have indicated that TBTO can cause immunotoxicity as an environ-mental pollutant. Male Wistar rats received an intramuscular injection of 0.5 ml/kg of TBTO. The most sensitive species was the cyprinid Alburnus alburnus with a 96 hr LC50 of 6-8 ugl TBTF. The activities of serum enzymes and the concentration of serum bilirubin were also analyzed. Toxicity values (mean effective concentration [EC50]) ranged from 2.97 to 18.5 μg/L for sperm cells and from 1.11 to 2.62 μg/L for embryos. Tributyltin (TBT), an organotin compound, is hazardous in aquatic ecosystems. We examined the effect of tributyltin (TBT) on the sex differentiation process in genetically female Japanese flounder (Paralichthys olivaceus).The fish were fed an artificial diet containing tributyltin oxide (TBTO) at concentrations of 0.1 and 1.0 μg/g diet from 35 to 100 d after hatching, which includes the sex differentiation period. 1 p. M & T Chemical Co. Jan. 1976. STP737 Bioaccumulation and Chronic Toxicity of Bis(tributyltin) Oxide (TBTO): Tests with a Saltwater Fish Acute toxicity of bis (tributyltin) oxide in the sweat glands in the rat footpad was investigated by electron microscopy and an energy-dispersive X-ray microanalyzer. Documents pertaining to 2004 Final Acute and Chronic Ambient Aquatic Life Water Quality Criteria for Tributyltin (TBT) for freshwater and saltwater. Human data summarized by Boyer (1989) suggest that tributyltin oxide is a potent non-allergenic dermal irritant. Tributyltin oxide (TBTO) is the main constituent of tin-based antifouling marine paint used on the hulls of ships to prevent the growth of fouling organisms. The study was initiated with embryos less than 24 h postfertilization and monitored through hatch, maturation, growth, and reproduction under continuous exposure to mean measured TBT concentrations of 5.4, 3.2, 1.3, 0.66, and 0.41 μg TBT/L. Articles of Tributyltin oxide are included as well. ------- —2— Registrations: nt.ifoulant paints containing tributyltin (TBT) compounds were initially registered in the early 1960’s. TBTO was shown to be hazardous to nontarget organisms. In a study of the chronic toxicity of TBT, Brooke et al. These documents include the safe levels of TBT that should protect the majority of species. Toxicity of Organotins in humans. Workers handling dibutyl- and tributyltin have reported eye irritation and skin lesions (1) and mucus irritation after exposure to interior paints containing tin ( 3). ENVIRONMENTAL TOXICITY DATA FOR CHEMICALS LISTED UNDER EPCRA SECTION 313 CAS NO. However, the mechanisms underlying TBT-induced central nervous system (CNS) toxicity remain to be determined especially in freshwater aquatic vertebrates. Its chemical formula is [ ( These workers also showed that dibutyltin, the major metabolite of tributyltin, is less effective in inducing apoptosis in vitro, suggesting that the in vivo toxicity is directly attributable to tributyltin. The results showed that TBTO is extremely toxic to O. niloticus with 96 h LC 50 of 16.3 μg L-1 using static renewal bioassay test. LC50s range from 6 to 240 ugl TBT. Neat tributyltin oxide (TBTO) was purchased from Sigma-Aldrich and used to prepare a The aim of this study was to assess the acute toxicity of TBT in seawater for the marine copepod T. biminiensis. Temmink, J. H. M., & Everts, J. W. (1988). At the initiation of the 3pecial Review there were 364 TBT anti— fouling paint formulations and 20 formulating intermediates with a total of 61 manufacturers. Because of the questionable data from the bioassay in rats, EPA assigns TBTO to the "cannot be determined" category [U.S. EPA, 1996 (proposed)]. CCME (1991 Appendix X) summarised the toxicity data for tributyltin for freshwater animals. PubMed:Toxicity of tributyltin and triphenyltin to early life-stages of Paracentrotus lividus (Echinodermata: Echinoidea). After 6-8 h, swelling of mitochondria appeared in the secretory cells of the sweat glands. and Anobium punctatum (Deg.) Acute Toxicity of Tributyltin Oxide … The enclosed Reregistration (bis)tributyltin oxide, tributyltin benzoate, and tributyltin maleate (collectively known as “tributyltin” or “TBT”). Based on its review, EPA is now releasing its Reregistration Eligibility Decision (RED) and risk management decision for tributyltin. Tributyltin oxide or Tri Butyl Tin Oxide TBTO Manufacturers, with SDS GHS MSDS Sheet: Muby Chemicals of Mubychem Group, established in 1976, is the original manufacturers of Specialty Chemicals, Pharmaceutical Excipient, Fragrance Food & Flavor chemicals, Reagent Grade Chemicals, Shale Gas Fracturing Chemicals in India. It is poorly soluble in water (20 ppm) but highly … toxicity in both water and sediment samples (ARAÚJO-CASTRO et al., 2009). Tributyltin oxide (TBTO) is an organotin compound chiefly used as a biocide (fungicide and molluscicide), especially a wood preservative.Its chemical formula is [(C 4 H 9) 3 Sn] 2 O. 7th World Meeting ORTEP Ass., J.A. The acute inhalation toxicity of Bio-Met-5, bis-tri-n-butyltin-oxide (56359) (Bio-Met-TBTO), tributyltin-fluoride (1983104) (TBTF) and tributyltin-benzoate (4342363) (TBTB) was investigated in Charles-River-rats. We investigated the toxicity of tributyltin oxide (TBTO) on spermatogenesis in a marine fish, mummichog, Fundulus heteroclitus. The Physico-chemical and Physiological Bases of Tributyltin Uptake by Mussels, Mytilus. Mubychem Group has several manufacturing facilities … Unless otherwise specified, all toxicity and environmental chemistry data presented are for tributyltin oxide, a representative compound. It is a colorless viscous liquid. The toxicity of tributyltin oxide to the wood‐boring beetles Lyctus brunneus Steph. Study organism for the adverse effects of nTiO2 were observed at 2 mg/L but concentrations ≥10 mg/L caused inhibition... Levels of TBT in seawater for the marine copepod T. biminiensis is hazardous in aquatic ecosystems respiratory the toxicity TBT... Were examined in a 180-day flow-through exposure of TBT, Brooke et al development cancer. Species of freshwater fish ranged from 2.6 µg/L to 13 µg/L 1991 Appendix X ) summarised the toxicity data CHEMICALS... 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